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Extracellular Messengers Report

2,000 words

Monoamines, Peptides, Proteins and Lipid based molecules can act as extracellular messengers to

regulate metabolic activity in vertebrate, invertebrate and plant cells. These messengers, often termed

Hormones, can alter the overall metabolism of the cell and organism or interact with each other by

changing the synthesis and/or degradation of other extra- and intra-cellular messengers.

Your task is to select any two (2) classes of extra-cellular messengers, which may include a peptide and a

protein, a protein and a lipid or a monoamine and a lipid based molecule, that interact with each other,

directly or indirectly, to alter the Metabolism (biochemical pathways within cells) in a vertebrate,

invertebrate or plant.

Excluded from the Report are Insulin (a protein), Glucagon (a peptide), Adrenaline (a monoamine)

and Cortisol (a lipid).

The Report should use the Headings below and address the following:

1. Overview

Identify the names, class and structure of the extra-cellular messenger molecules and contextualize

the intracellular metabolic (biochemical) pathways they affect. Outline the effect(s) the extracellular

messengers have (individually and in combination) on the organism locally (i.e. specific cells or

tissue) and/or as a whole (i.e. the whole organism). Briefly outline the precursors and the

biochemical steps to produce the extracellular messengers (i.e. parent molecule, key enzymes &

cofactors involved in synthesis) and the fate of the extracellular messengers following their action

(i.e. messenger degradation).

2. Biochemical Pathways

Describe the biochemical pathway(s), including key enzymes/cofactors and intermediates, directly

affected by the extracellular messengers selected.

3. Disease States

Identify the disease state(s)/or consequence(s) of the extracellular messengers that arise if there is a

chemical perturbation or genetic defect anywhere in the biosynthetic pathway of the extracellular

messengers or their target cells.

4. Remediation

Briefly describe the strategy used to overcome the disease state as a consequence of extracellular

messenger dysfunction.

Report Format.

Diagrams maybe used (with appropriate references). The report should be in 12pt font, <2,000

words, with Vancouver referencing format (labelled as superscript numbers throughout the text and

identified in the References, Website(s) should include accession dates).

Note: References and diagram/legends are not included in the word count

Compétences : Rédaction de Rapport

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